Evaluation of Brain Opioid Receptor Activity in Anorexia Nervosa : a PET [11C]Diprenorphine Study
Status:
Completed
Trial end date:
2016-07-29
Target enrollment:
Participant gender:
Summary
The place of opioid system in anorexia nervosa (AN) physiopathology is still unclear.
Conflicting results were published on cerebral spinal fluid or peripheral levels in anorexia
nervosa. However, no data have been reported on opioid cerebral activity. Diprenorphine is a
ligand with non-selective binding to opiate receptors µ, κ and δ capable to assess the
interaction between endogenous opioids and their receptors.